You Were Born With a Third Set of Teeth — And Science Is Learning How to Wake Them Up | April 5, 2025

Imagine losing a tooth and growing a brand-new one—no implants, no dentures, just your own body regenerating what it was always capable of.

This futuristic idea is no longer science fiction. Thanks to a breakthrough by Japanese researchers, we may soon be able to naturally regrow human teeth—a biological ability once thought to be lost to evolution.

The Hidden Potential Inside Your Jaw

Most people know about two sets of teeth: your baby (primary) teeth and your adult (permanent) teeth. But what many don’t realize is that you were also born with the genetic blueprint for a third set. These extra teeth exist as dormant buds buried deep within the jaw—silent, undeveloped, and until now, unreachable.

Japanese scientists have identified a molecule known as USAG-1 that actively suppresses these third tooth buds from developing. In animal studies, they discovered that blocking this molecule allowed new teeth to grow naturally.

Turning the Switch Back On

The team developed a drug that inhibits USAG-1, effectively removing the barrier and allowing the dormant buds to awaken and grow into full teeth. After promising results in animal models, human clinical trials began in late 2024, with the goal of making this treatment publicly available by 2030.

If these trials prove successful, the implications are enormous.

• People who’ve lost teeth due to injury, decay, or aging could grow new ones without surgery.

• Children born with missing teeth (a condition called congenital anodontia) could finally develop a complete set.

• Dentures and implants may eventually become obsolete.

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